The pancreas has two major roles. It produces insulin, which helps the body manage and use sugars.
The pancreas also produces dietary juices, called enzymes, that help with digestion. The pancreas makes and stores "turned off" versions of the enzymes. After the pancreas sends the enzymes into the small intestine, they are "turned on" and break down proteins in the small intestine.
If the enzymes are turned on too soon, they can start acting like digestive juices inside the pancreas. The action can irritate, damage or destroy cells. This problem, in turn, leads to immune system responses that cause swelling and other events that affect how the pancreas works.
Several conditions can lead to acute pancreatitis, including:
- Blockage in the bile duct caused by gallstones.
- Heavy alcohol use.
- Certain medicines.
- High triglyceride levels in the blood.
- High calcium levels in the blood.
- Pancreas cancer.
- Injuries from trauma or surgery.
Conditions that can lead to chronic pancreatitis include:
- Damage from repeated acute pancreatitis.
- Heavy alcohol use.
- Inherited genes linked to pancreatitis.
- High triglyceride levels in the blood.
- High calcium levels in the blood.
Sometimes, a cause for pancreatitis is never found. This is known as idiopathic pancreatitis.