Treatment for shigella infection depends on how serious the illness is. Most often, the illness is mild and gets better within seven days. You may only need to replace lost fluids from diarrhea, especially if your overall health is good.
Medicines sold without a prescription
Talk to your healthcare professional before you take any diarrhea medicine that's sold without a prescription. Many conditions can cause diarrhea, and these medicines could make some conditions worse.
If a lab test has confirmed that you have shigella infection, medicine that contains bismuth subsalicylate (Pepto-Bismol, Kaopectate) may help. This is available without a prescription. It may help you pass stool less often and shorten the length of your illness. But it isn't recommended for children, pregnant or breastfeeding people, or people who are allergic to aspirin.
Do not take diarrhea medicines such as loperamide (Imodium A-D). Also, do not take medicines that contain the combination of diphenoxylate and atropine (Lomotil). These aren't recommended for shigella infection. They can lower the body's ability to clear shigella germs and make your condition worse.
Antibiotics
For a serious shigella infection, your healthcare professional may recommend medicines called antibiotics that help get rid of germs. Antibiotics may shorten the length of the illness. But some shigella bacteria resist the effects of these medicines. So your healthcare professional may not recommend antibiotics unless your shigella infection is very bad.
Antibiotics also may be needed to treat infants, older adults and people with weakened immune systems. Antibiotics also may be used if there's a high risk of spreading the disease.
If you're given antibiotics, take them exactly as prescribed. Finish taking all the pills even if you start to feel better.
Fluid and salt replacement
For adults in good health overall, drinking water may be enough to prevent dehydration caused by diarrhea.
Children may benefit from a treatment called oral rehydration solution, such as Pedialyte. This is sold in drugstores and taken by mouth. Many pharmacies carry their own brands.
Children and adults who are very dehydrated need treatment in a hospital emergency room. Treatment involves salts and fluids given through a vein rather than by mouth. This is called intravenous hydration. It provides the body with water and essential nutrients much more quickly than oral solutions do.