Dyslipidemia is a high level of cholesterol, triglycerides or both, or a low level of the "good" cholesterol, high-density lipoprotein (HDL) cholesterol, in the blood. Genetics, lifestyle and other factors can cause dyslipidemia. Dyslipidemia increases the chance of clogged arteries, known as atherosclerosis. It also increases the risk of heart attacks, strokes or other circulatory concerns.