In rheumatoid arthritis, the body's immune system attacks its own tissue, typically in the hands and feet. In some people, the condition can damage body systems including the skin, eyes, lung, heart and blood vessels.

It affects joint linings, causing painful swelling. This may lead to bone erosion and joint deformity. Fatigue, fever and loss of appetite also can be symptoms.

Medicines, physical therapy, and surgery aim to control symptoms and prevent joint damage.