Signs and symptoms of adrenal cancer may include:

• Back pain.
• Belly pain.
• Losing weight without trying.
• Loss of appetite.

Many people who have adrenal cancer develop hormone changes in the body. These changes can happen if the cancer cells make extra hormones. Most often, the adrenal cancer makes the hormone cortisol. This can cause symptoms of Cushing syndrome, including:

• Weight gain.
• Muscle weakness.
• Pink or purple stretch marks on the skin.
• Bruises that happen even with a small injury.
• High blood pressure.
• High blood sugar or diabetes.

Less often, an adrenal cancer might make the sex hormones estrogen and testosterone. In females, changes in the sex hormones can cause extra facial hair, hair loss on the head and periods that aren't regular. In males, these hormone changes may cause the testicles to shrink and breast tissue to get bigger.

Rarely, adrenal cancer may make the hormone aldosterone. That can cause high blood pressure and low levels of potassium in the blood.

When to see a doctor

Make an appointment with a healthcare professional if you have any symptoms that worry you.

It's not clear what causes adrenal cancer.

Adrenal cancer happens when cells in the adrenal gland develop changes in their DNA. A cell's DNA holds the instructions that tell the cell what to do. In healthy cells, the DNA tells the cells to grow and multiply at a set rate. The DNA also tells the cells to die at a set time.

In cancer cells, the DNA changes give different instructions. The changes tell the cancer cells to grow and multiply quickly. Cancer cells can keep living when healthy cells would die. This causes too many cells.

The cancer cells might form a mass called a tumor. The tumor can grow to invade and destroy healthy body tissue. In time, cancer cells can break away and spread to other parts of the body. When cancer spreads, it's called metastatic cancer.

Adrenal cancer happens more often in people who inherit certain health conditions that raise the risk of some cancers. Those health conditions include:

• Beckwith-Wiedemann syndrome.
• Familial adenomatous polyposis.
• Li-Fraumeni syndrome.
• Lynch syndrome.
• Multiple endocrine neoplasia, type 1, also called MEN 1.

Healthcare professionals haven't found anything that can prevent adrenal cancer.

To diagnose adrenal cancer, a healthcare professional might start with a physical exam and review of your health history and family medical history. Diagnosis also involves blood and urine tests and imaging tests. Sometimes, surgery to remove the adrenal gland may be needed to diagnose adrenal cancer.

Blood and urine tests

Lab tests of blood and urine may show levels of hormones made by the adrenal glands that are outside a healthy range. Those hormones include cortisol, aldosterone and androgens.

Imaging tests

Imaging tests used to diagnose adrenal cancer include CT, MRI and positron emission tomography scans, also called PET scans. Healthcare professionals might use the images to examine growths on the adrenal glands. Imaging tests also can look for signs that the cancer has spread to other areas of the body.

Surgery to remove the adrenal gland

In some situations, to make a diagnosis of adrenal cancer, the adrenal gland that might have cancer is removed with surgery. Then, the gland is examined in a lab by a doctor who studies body tissues, called a pathologist. Testing can show whether the gland has cancer.

Treatment for adrenal cancer often includes surgery to remove the adrenal gland. Other treatments also might be used in some situations. Those treatments include radiation therapy and medicines, such as chemotherapy and immunotherapy.

Surgery

Surgery for adrenal cancer typically involves removing the entire adrenal gland. This procedure is called an adrenalectomy. The surgery is done for several reasons, including to:

• Confirm a diagnosis of adrenal cancer.
• Remove as much of the cancer as possible.
• See if cancer has spread outside the adrenal gland.
• Ease symptoms. This can include lessening symptoms that happen when the body makes too much of the hormone cortisol due to cancer. Surgery also may help with symptoms such as belly pain and back pain that happen when an adrenal cancer grows large.

It's common for adrenal cancer to spread outside of the adrenal gland. If the surgeon finds evidence that the cancer has spread to nearby organs, such as to the liver or kidney, parts or all of those organs also might need to be removed.

Radiation therapy

Radiation therapy treats cancer with powerful energy beams. The energy can come from X-rays, protons or other sources. Radiation therapy sometimes is used after adrenal cancer surgery to kill any cells that might be left behind. It also can help ease pain and other symptoms of cancer that has spread to other parts of the body, such as the bones.

Chemotherapy

Chemotherapy treats cancer with strong medicines. For adrenal cancers that can't entirely be removed with surgery or those that come back after surgery, chemotherapy may help keep the cancer from growing and spreading.

Mitotane

Mitotane (Lysodren) is an older medicine that has been used to treat advanced adrenal cancer. It also has shown promise in keeping adrenal cancer from coming back after surgery. Mitotane may be used after surgery for people who are at high risk of the cancer coming back. Research into mitotane for this purpose is ongoing.

Immunotherapy

Immunotherapy for cancer is a treatment with medicine that helps the body's immune system kill cancer cells. The immune system fights off diseases by attacking germs and other cells that shouldn't be in the body. Cancer cells survive by hiding from the immune system. Immunotherapy helps the immune system cells find and kill the cancer cells.

For adrenal cancer, immunotherapy may be used when the cancer has spread to other parts of the body or in situations where surgery isn't possible.

With time, you'll find things that help you cope with an adrenal cancer diagnosis. Until you find what works best for you, here are some ideas for coping.

Learn more

Learn enough about adrenal cancer to help you make decisions about your care. Ask your healthcare team about your cancer. Understand your test results and treatment choices. Some people want to know about their outlook for a cure. Others don't. Make the choice that feels right for you. As you learn more about adrenal cancer, you may become more confident in making decisions.

Find a good listener

Finding someone who is willing to listen to you talk about your hopes and fears can be helpful as you manage a cancer diagnosis. This could be a friend or family member. A counselor, medical social worker, clergy member or cancer support group also may offer helpful guidance and care.

Ask a member of your healthcare team about support groups and other resources in your area. You also can learn more from organizations that offer support for people with cancer. In the United States, examples include the National Cancer Institute and the American Cancer Society.

Start by making an appointment with a healthcare professional if you have any symptoms that worry you.

Because appointments may be short, it's a good idea to be prepared. Here's some information to help you get ready.

What you can do

• Be aware of anything you need to do before your appointment. When you make the appointment, ask if there's anything you need to do to get ready. For example, you may need to stop eating or drinking for a certain amount of time before your appointment.
• Write down any symptoms you have. Include any that may not seem related to the reason why you scheduled the appointment.
• Write down key personal information. Include any major stresses or recent life changes. Family medical history also can be helpful.
• Make a list of all medicines, vitamins or supplements that you take.
• Consider taking a family member or friend along. Sometimes it can be hard to remember all the information you get during an appointment. Someone who comes with you may remember something that you missed or forgot.
• Write down questions to ask your healthcare professional.

Bringing a list of questions to your appointment can help you make the most of the time with your healthcare professional. For adrenal cancer, some basic questions to ask include:

• What's likely causing my symptoms?
• Other than the most likely cause, what are other possible causes for my symptoms?
• What tests do I need?
• What's the best course of action?
• What are the alternatives to the approach you're suggesting?
• I have other health conditions. How can I best manage them together?
• Are there restrictions I need to follow?
• Should I see a specialist?
• Are there brochures or other printed material I can have? What websites do you recommend?

Don't hesitate to ask other questions you may have too.

What to expect from your doctor

Your healthcare professional is likely to ask you some questions, including:

• When did your symptoms begin?
• Do you have symptoms all the time, or do they come and go?
• How serious are your symptoms?
• What, if anything, seems to make your symptoms better?
• What, if anything, seems to make your symptoms worse?