The most common cause of hand-foot-and-mouth disease is infection from coxsackievirus 16. This coxsackievirus belongs to a group of viruses called nonpolio enteroviruses. Other types of enteroviruses also may cause hand-foot-and-mouth disease.
Most people get the coxsackievirus infection — and hand-foot-and-mouth disease — through the mouth. The illness spreads by person-to-person contact with an infected person's:
- Nose secretions or throat discharge
- Saliva
- Fluid from blisters
- Stool
- Respiratory droplets sprayed into the air after a cough or sneeze
Common in child care setting
Hand-foot-and-mouth disease is most common in children in child care. That's because young children need frequent diaper changes and help using the toilet. They also tend to put their hands in their mouths.
Your child is most contagious during the first week of having hand-foot-and-mouth disease. But the virus can remain in the body for weeks after the symptoms go away. That means your child still can infect others.
Some people, especially adults, can pass the virus without showing any symptoms of the disease.
Outbreaks of the disease are more common in summer and early autumn in the United States. In tropical climates, outbreaks occur during the rainy season.
Different from foot-and-mouth disease
Hand-foot-and-mouth disease isn't related to foot-and-mouth disease (sometimes called hoof-and-mouth disease), which is an infectious viral disease found in farm animals. You can't get hand-foot-and-mouth disease from pets or other animals, and you can't spread it to them.