Trigeminal neuralgia treatment usually starts with medications, and some people don't need any additional treatment. However, over time, some people with the condition may stop responding to medications, or they may experience unpleasant side effects. For those people, injections or surgery provide other trigeminal neuralgia treatment options.
If your condition is due to another cause, such as multiple sclerosis, you need treatment for the underlying condition.
Medications
To treat trigeminal neuralgia, healthcare professionals prescribe medicines to lessen or block the pain signals sent to your brain.
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Anti-seizure medicines. Healthcare professionals often prescribe carbamazepine (Tegretol, Carbatrol, others) for trigeminal neuralgia. It has been shown to be effective in treating the condition.
Other anti-seizure medicines that may be used include oxcarbazepine (Trileptal, Oxtellar XR), lamotrigine (Lamictal), and phenytoin (Dilantin, Phenytek, Cerebyx). Other medicines that may be used include topiramate (Qudexy XR, Topamax, others), pregabalin (Lyrica) and gabapentin (Neurontin, Gralise, Horizant).
If the anti-seizure medicine you're using becomes less effective, your healthcare professional may increase the dose or switch to another type. Side effects of anti-seizure medicines may include dizziness, confusion, drowsiness and nausea. Also, carbamazepine can trigger a serious reaction in some people, mainly in those of Asian descent. Genetic testing may be recommended before you start carbamazepine.
- Muscle relaxants. Muscle-relaxing medicines such as baclofen (Gablofen, Fleqsuvy, others) may be used alone or in combination with carbamazepine. Side effects may include confusion, nausea and drowsiness.
- Botox injections. Small studies have shown that onabotulinumtoxinA (Botox) injections may reduce pain from trigeminal neuralgia in people who are no longer helped by medicines. However, more research needs to be done before this treatment is widely used for this condition.
Surgery
Surgical options for trigeminal neuralgia include:
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Microvascular decompression. This procedure involves moving or removing blood vessels that touch the trigeminal nerve to stop the nerve from malfunctioning. A cut, known as an incision, is made behind the ear on the side where you feel the pain. Then, through a small hole in your skull, your surgeon moves any arteries that are in contact with the trigeminal nerve. The surgeon also places a soft cushion between the nerve and the arteries.
If a vein is compressing the nerve, your surgeon may remove it. Part of the trigeminal nerve may be cut if arteries aren't pressing on the nerve. This is known as a neurectomy.
Microvascular decompression can stop or reduce pain for many years. Long-term pain relief depends on the location of pain, type of pain and age of the person. People with a blood vessel that is seen to be compressing the nerve can remain pain free for years after the procedure. Only a small number of people may have pain come back in 3 to 5 years after surgery. Microvascular decompression has some risks, including decreased hearing, facial weakness, facial numbness, stroke or other complications. Most people who have this procedure have no facial numbness afterward.
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Brain stereotactic radiosurgery, also known as Gamma Knife. In this procedure, a surgeon aims a focused dose of radiation to the root of the trigeminal nerve. The radiation damages the trigeminal nerve to reduce or stop pain. Pain relief occurs gradually and may take up to a month.
Brain stereotactic radiosurgery is successful in stopping pain for most people. But like all procedures, there is a risk that pain may come back, often within 3 to 5 years. If pain returns, the procedure can be repeated or you may have another procedure. Facial numbness is a common side effect, and may occur months or years after the procedure.
Other procedures may be used to treat trigeminal neuralgia, such as a rhizotomy. In a rhizotomy, your surgeon destroys nerve fibers to reduce pain. This causes some facial numbness. Types of rhizotomy include:
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Glycerol injection. A needle that goes through the face and into an opening in the base of the skull delivers medicine to reduce pain. The needle is guided to a small sac of spinal fluid that surrounds the area where the trigeminal nerve divides into three branches. Then a small amount of sterile glycerol is injected. The glycerol damages the trigeminal nerve and blocks pain signals.
This procedure often relieves pain. However, pain returns in some people. Many people experience facial numbness or tingling after a glycerol injection.
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Balloon compression. This procedure involves inserting a hollow needle through the face. It's guided it to a part of the trigeminal nerve that goes through the base of the skull. Then a thin, flexible tube called a catheter with a balloon on the end is threaded through the needle. The balloon inflates with enough pressure to damage the trigeminal nerve and block pain signals.
Balloon compression successfully controls pain in most people, at least for a period of time. Most people undergoing this procedure experience at least some temporary facial numbness.
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Radiofrequency thermal lesioning. This procedure selectively destroys nerve fibers associated with pain. While you're sedated, your surgeon inserts a hollow needle through your face. The surgeon guides the needle to a part of the trigeminal nerve that goes through an opening at the base of your skull.
Once the needle is positioned, your surgeon briefly wakes you from sedation. Your surgeon inserts an electrode through the needle and sends a mild electrical current through the tip of the electrode. You're asked to say when and where you feel tingling.
When your surgeon locates the part of the nerve involved in your pain, you're returned to sedation. Then the electrode is heated until it damages the nerve fibers, creating an area of injury known as a lesion. If the lesion doesn't get rid of your pain, your doctor may create additional lesions.
Radiofrequency thermal lesioning usually results in some temporary facial numbness after the procedure. Pain may return after 3 to 4 years.