High triglycerides may contribute to hardening of the arteries or thickening of the artery walls (arteriosclerosis) — which increases the risk of stroke, heart attack and heart disease. Extremely high triglycerides can also cause acute inflammation of the pancreas (pancreatitis).
High triglycerides are often a sign of other conditions that increase the risk of heart disease and stroke, including obesity and metabolic syndrome — a cluster of conditions that includes too much fat around the waist, high blood pressure, high triglycerides, high blood sugar and abnormal cholesterol levels.
High triglycerides can also be a sign of:
- Type 2 diabetes or prediabetes
- Metabolic syndrome — a condition when high blood pressure, obesity and high blood sugar occur together, increasing your risk of heart disease
- Low levels of thyroid hormones (hypothyroidism)
- Certain rare genetic conditions that affect how your body converts fat to energy
Sometimes high triglycerides are a side effect of taking certain medications, such as:
- Diuretics
- Estrogen and progestin
- Retinoids
- Steroids
- Beta blockers
- Some immunosuppressants
- Some HIV medications